Disorders of Neurohypophysis - Excess vasopressin secretion and action - Hyponatremia

6 important questions on Disorders of Neurohypophysis - Excess vasopressin secretion and action - Hyponatremia

What are the characteristics of Hyponatremia?

  • excess water retention
  • very concentrated urine

Which kinds of hyponatremia do you have?

  • Gradually (asymptomatic)
  • Acutely (symptomatic)

What happens when you have the most common form of hyponatremia?

The threshold of the osmoregulators lies lower than it normally does, thus secreting more AVP at the same osmolaric fluid pressure resulting in retention of more water.
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What are the types of Hyponatremia?

  1. Sodium retaining, edema
  2. Stim. of ADH by low BV or BP
  3. Nonosmotic, non hemodynamic AVP stimuli

Where does SIAD lead to?

  • Excessive ADH secretion
  • Excessive water retention
  • Hyponatremia   

What happens by excessive water retention?

  • increased glomular volume filtering
  • increased extracellular fluid

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