Thyroid hormone synthesis, metabolism and action - Thyroid hormone synthesis - Iodine metabolism and transport

15 important questions on Thyroid hormone synthesis, metabolism and action - Thyroid hormone synthesis - Iodine metabolism and transport

To which glycoprotein is ingested Iodine bound?

Albumin

By which system is the Iodine uptake regulated?

By the Na+/I- symporter

At which is other glands is the NIS system also located?

At the

  • salivary glands
  • lactating glands
  • placenta
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Why is the presence of the NIS system in the placenta important?

To supply the fetus of Iodine for thyroid hormone production.

How is the NIS regulated by Iodide?

High iodide:
Low NIS system
Low iodide
High NIS system

Where is the NIS system located?

At the basolateral membrane

Where is the pendrin system located?

At the apical side of the follicle cell.

What is the function of the pendrine system?

The transport of Iodide from the cell into the colloid to iodificate the Tg.

In which areas is a iodine deficiency more common?

In mountainious regions

Which disease comes with mild iodine deficiency?

Goiter

Which disease comes with severe iodine deficiency?

  • Hypothyroidism
  • cretinism

What are the characteristics of cretinism?

mental and growth retardation

How is cretinism treated?

By Iodine suppletion

What is the recommended average daily intake of Iodine?

150-250microg/day for adults
90-120 microg/day for children
250microg/day for pregnant women

Under which urine iodine concentration can iodine-insufficiency be detected?

Under 10microg/dL

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