Hypothalamic and anterior pituitary insufficiency - Developmental and genetic causes of hypopituitarism - Developmental hypothalamic dysfunction

5 important questions on Hypothalamic and anterior pituitary insufficiency - Developmental and genetic causes of hypopituitarism - Developmental hypothalamic dysfunction

What causes the Kallmann syndrome?

A dysfunction in the gnRH hypothalamic hormone synthesis.

How is the Kallmann syndrome characterized?

  • low LH
  • low FSH
  • low steroidlevels

What is the Bardet-Biedl syndrome?

This is an genetic heterogenous disorder that causes mental retardation, renal abnormalities, obesity
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The production of which anterior pituitary hormone seems to be compromised in Bardet-Biedl?

LH and FSH

Name some hypothalamic abnormalities observed by patients with Leptin and leptin receptor mutations.

  • obesity
  • hyperphagia
  • hypogonadism

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