Thyroid hormone synthesis, metabolism and action - Thyroid hormone synthesis - Organification, coupling, storage, release

7 important questions on Thyroid hormone synthesis, metabolism and action - Thyroid hormone synthesis - Organification, coupling, storage, release

Which important thyroid membrane protein induces the coupling of I-?

The TPO protein

Which two proteins involve the oxidation of I-?

TPO and hydrogen peroxidase

To which part of the Tg is reactive iodide added?

To the tyrosyl residues at the Tg.
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Which protein catalyzes the coupling of T1 and T2?

TPO

What happens with Tg when it has all the iodotyrosines coupled?

It is reuptaken by the follicle cell and then proteolysed.

By which enzyme are T1 and T2 deiodinated?

dehalogenase

Which structures of the follicle cells are most common to mutations?

Tg and TPO

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