Disorders of the Thyriod Gland - Thyroid hormone synthesis, metabolism and action - Thyroid hormone synthesis

4 important questions on Disorders of the Thyriod Gland - Thyroid hormone synthesis, metabolism and action - Thyroid hormone synthesis

What is the reaction on TSH-a binding to a TSH-Receptor?

adenylyl cyclase gets activated which promotes the formation of cAMP

Which diseases are caused by a defect in the TSH-R?

  • thyroid hypoplasia
  • congenital hypothyroidism

Which factors, other than TSH, influence the growth and function of the thyroid follicles?

  • IGF-1
  • EGF
  • TGF-b
  • cytokines
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What is the Wolff-CHaikoff effect?

The organification of Iodide by hydrogen peroxidase and TPO is supressed.

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