Disorders of the Thyriod Gland - Regulation of the thyroid axis

7 important questions on Disorders of the Thyriod Gland - Regulation of the thyroid axis

What is the most usefull phyiological marker of thyroid hormone action?

TSH

Which hormone regulates the function of TSH?

TRH and Vasopressin

Which hormone is the masterregulator in the thyroid axis?

TSH by binding the TRb2 receptors
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How long does it take TSH to peak after administration of exogenous TRH?

15mins

Which hormones are the dominant regulators of TSH?

T3 and T4

What makes TSH measurement more adequate than the measurement of other anterior pituitary hormones?

TSH has a relatively longer plasma halflife than the other pituitary hormones.

Are TSH levels high or low in Hypothyroidism?

High, because hypothyroidism is a shortage of T3/T4. These hormones inhibit the production of TSH and therefore TSH levels are high.

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