Clinical disorders - Primary hemostasis - Von Willebrand disease
5 important questions on Clinical disorders - Primary hemostasis - Von Willebrand disease
What are the characteristics of VWD type 2? And what are the subtypes of type 2 VWD?
Autosomal dominant and 2N is autosomal recessive.
- 2A: decreased function due to the absence of high molecular weight multimeres
- 2B: increased affinity for GPIb receptor, reduced number of platelets. VWF binds spontaneously to platelets and when there is a bleeding there is not enough platelets.
- 2M: normal size, but VWF does not attach to the platelets normally
- 2N: VWF does not attach to FVIII normally
What are the treatment options for VWD?
- DDAVP
- Tranexamic acid
- VWF concentrate
What is the working mechanism of DDAVP?
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DDAVP is contra-indicated to which types of VWD?
It only works for type 1 and some type 2.
What is the working mechanism of tranexaminic acid?
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
