Congenital - Congenital thrombotic disorders

9 important questions on Congenital - Congenital thrombotic disorders

What are the thrombotic risks and recurrent risk of thrombosis in factor V Leiden?

Thrombotic risk: 3-5 fold increased risk of VTE
Recurrent thrombotic risk: not a higher risk

What is the mechanism of prothrombin gene mutation?

Prothrombin levels are increased with 30% din heterozygotes and 70% in homozygotes. Due to the increasement of prothrombin, there will be more risk of thrombis

What are the thrombotic risk for prothrombin gene mutations?

Thrombotic risk: 2-4 fold increased risk of VTE
  • Higher grades + faster learning
  • Never study anything twice
  • 100% sure, 100% understanding
Discover Study Smart

What is the mechanism of antithrombin deficiency?

Heterozygotes mutation of antithrombin leading to reduced inhibition of FXa and thrombin and therefore increased thrombin generation.

What is the risk of thrombosis in patients with antithrombin deficiency?

The absolute risk of VTE is 2% per year. This is really high. It is a dangerous disease, you want to give five prophylaxes for preventing bleeding.

What is the mechanism of protein C/S deficiency?

Heritable deficiencies lead to impaired inactivation of FVa and FVIII and thereby increase thrombin generation. Infants will die early because of this disease.

How do you treat protein C/S deficiency?

Very rapid diagnosis and treatment with protein C and heparin

What is the general treatment of congenital disorders of thrombosis?

  • Age dependent
  • local hemostasis
  • tanexamic acid
  • DDAVP
  • thrombnocyte transfusion: large wounds
  • recombinant FVIIa
  • thrombopoietin agonists

When do you do family testing in cases of congenital thrombotic disorders?

Protein C/S deficiency
Combination of factor V leiden and antithrombin

The question on the page originate from the summary of the following study material:

  • A unique study and practice tool
  • Never study anything twice again
  • Get the grades you hope for
  • 100% sure, 100% understanding
Remember faster, study better. Scientifically proven.
Trustpilot Logo