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1 Het zenuwstelsel
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1.1 Neuronale communicatie
This is a preview. There are 21 more flashcards available for chapter 1.1
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Neuron: dendritic spine
Transmitter detection -
Neuron: terminal brances of axons
Form junctions with other cells -
5 classes neurons characteristics
Nr ofneurites : uni-,bi-,multipolar
Shapedendrites :pyramidal , stellate, purkinje cells
Length of axon: projection/interneurons
Function: afferent/efferent neurons
Transmitter secretion: glutamergic, dopaminergic, cholinergic -
Humain brain contains ... Neurons
3-5billion
1.6x10^11 in cerebral cortex
10^11 in cerebellum -
Intracellular recording in a neuron
Intracellular recording is an electrophysiology technique that inserts a glass microelectrode into a single cell (usually a neuron) to precisely measure its electrical activity (voltages across or currents passing through the cellular membranes). It can allow the recordings of slower graded voltages (receptor potentials or synaptic potentials), which would be vital in studies involving neural signalling. -
What causes a neuron to be depolarized or hyperpolarized?
Experimental :
-injection ofhyperpolarizing (outward) ordepolarizing (inward) current
-application ofchemical stimulus
In the brain:
-synaptic inputs from otherneurons (neurotransmitters )
-input sensory organs -
VGICs and delta- and meta-conotoxins (CTX)
Sodium channel blockers -
VGICs and Saxitoxin (STX)
Sodium channel blockers -
VGICS and tetrodotoxin (TTX)
Sodium channel blockers -
Pharmacolocy and VGICs: Potassium channel activators
Antihypertensives (diazoxide)
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