Neuronale ontwikkeling

4 important questions on Neuronale ontwikkeling

Neurulation: neural tube, notochord, neural chrest become...

Neural tube: central nervous system (brain and spinal cord)
Notochord: vertebral column
Neural crest: peripheral nervous system

Spatiotemporally controlled gradient of retinoic acid

retinoic acid forms a gradient along the anteroposterior axis of the embryo, with higher concentrations at one end (e.g., posterior) and lower concentrations at the other end (e.g., anterior).

Neurogenesis: Ventricular zone

-Neuroepithelial stem cells (earliest stem cells)
-Generates projection neurons (communication & integration)
-Only active during development
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Neurons migration defects (4)

Microcephaly (small brain), initiation defect
Lissencephaly (double cortex), ongoing migration
Inverted cortical layering (cerebellar hypoplasia), lamination defect
Walker-warburg syndrome (Cobbleston cortex), stop signal defect

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