Neuronale ontwikkeling
4 important questions on Neuronale ontwikkeling
Neurulation: neural tube, notochord, neural chrest become...
Notochord: vertebral column
Neural crest: peripheral nervous system
Spatiotemporally controlled gradient of retinoic acid
Neurogenesis: Ventricular zone
-Generates projection neurons (communication & integration)
-Only active during development
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Neurons migration defects (4)
Lissencephaly (double cortex), ongoing migration
Inverted cortical layering (cerebellar hypoplasia), lamination defect
Walker-warburg syndrome (Cobbleston cortex), stop signal defect
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