L10 pharmacology of inflammation

3 important questions on L10 pharmacology of inflammation

A generic and functional response to a inflammation

  • Heat
  • redness
  • swelling
  • pain
  • loss of function

The major local manifestations of acute inflammation, compare to normal:

  1. Vascular dilation and increased blood flow (causing erythema and warmth)
  2. extravasation and deposition of plasma fluid and proteins (edema), and
  3. leukocyte (mainly neutrophil)emigration and accumulation in the site of injury.

The cycle-oxygenase pathway of NSAID GI toxicity

Met COX 1 en COX 2

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