L8 pharmocology of weight management and complications of obesity

4 important questions on L8 pharmocology of weight management and complications of obesity

Medical options for weight los --> bariatric surgery

  • Effective but not the 'ideal solution'
  • only indicated in very obese or patients ar risk
  • not to be confused with liposuction

Key messages from Pharma R&D:

  1. Overweight creates big market
  2. creativity is unlimited
  3. no idea is too crazy beforehand
  4. consider options you thought unthinkable

Second generation CB1 blockers -->

  • Different kinetics: relatively lower brain concentrations and more peripheral action
  • different dynamics: no inverse agonists like rimonabant, but neutral antagonists or partial agonists
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Physical excursive is beneficial

  • Improves symptoms of metabolic syndrome independently from weight loss
  • improves cardiometabilic fitness
  • improves muscle metabolism
  • stimulates immune system
  • contributes to weight management

The question on the page originate from the summary of the following study material:

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