Calcium homeostasis

9 important questions on Calcium homeostasis

What happens when the Ca2+ concentration increases?

PTH secretion by the parathyroid cells goes up.

How is primary hyperparatyroidism treated?

By surgery/resection of the adenoma/hyperplasia.

What is a comorbidity of secondary hyperparatyroidism?

Renal failure
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What is the importance of Phosphate to Calcium and boneformation?

P stimulates Ca2+ resorption by the bone.

Why do sea-animals have high serum levels of Calcitonin?

Because the waters are high in Ca2+ concentrations and therefore organisms need to lower their Ca2+ levels actively.

What is the action of Calcitonin on the blood Ca2+ concentration?

It lowers the release of Ca2+ of tissues and therefore lowers [Ca2+] in the blood.

What action does Vitamin D have in pregnant women?

It promotes Ca2+ metabolism favouring the embryo..

How can hypercalcemia due to a malignancy be diagnosed?

Low PTH and high Ca2+

When do you operate in Primary hyperparathyroidism?

  • Serum Ca2+ > 1mg/dl
  • 24hr urine Ca2+ is normal
  • Creatinine clearance <60ml/min
  • bone density T < -2.5
  • Age under 50

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