Genetic association analsysi and candidate genes

4 important questions on Genetic association analsysi and candidate genes

What are the two main drawbacks of linkage studies?

Very low power
Positive results are very broad

What two results do meta-analysis give?

If the results are statistically homogenous
Gives an aggregate estimate of the effect under study that is properly averaged overall the studies

What is the advantage of association studies in comparison to linkage?

Greater power and focus but casts a narrower net and requires knowing enough to nominate candidate genes
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What is a strategy for enhancing effect size of association study?

To use endophenotypes which are closer to the site of genetic action, such as brain area activation. Since biological traits are expected to be closer to the genes.

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