B Cells and antibodies
7 important questions on B Cells and antibodies
Kenmerken/eigenschappen van B cell receptor (BCR)
- B cells are born in the bone marrow
- 1.000.000.000 B cells are born each day!
- during development each B cell selects its heavy and light chain that make the BCR
- the BCR is almost identical ti the antibodies this B cell can produce (antibodies lack the transmembrane anchor, they are released)
What is the function of the Igalfa and Igbeta molecules?
Therefore, the BCR has it's second part on the inside of the cell. The Igalfa and Igbeta proteins don't see what's going on, but they can signal to the nuclear what happens outside the cell.
Can you give two advantages of T cell-independent activation, relative to T cell-dependent activation?
Wider target: not only reaction against proteins, but also carbohydrates and fat
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After being activated, the B cells are ready for the next step in their life: maturation!
we can divide this in 3 steps:
- Class switching
- somatic hypermutation
- Career choice
What makes IgA antibodies so good in defending these mucosal surfaces?
The two tails of the IgA antibody are clipped together, what facilitates the antibody across the intestinal wall and make them resistant to acids and enzymes!
The 'clip' prevents the IgA antibodies from complement binding. Why is this a good thing?
Can you explain what happens when the B cell undergoes somatic hypermutation?
The question on the page originate from the summary of the following study material:
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