Mesoderm & skeleton
30 important questions on Mesoderm & skeleton
When does mesoderm formation take place, and from what does it develop?
- Epiblast cells form between epiblast and hypoblast to form intraembryonic mesoderm.
What controls the mesoderm cell-specification?
Where do the different muscle types develop from?
- Smooth muscles:
- in gut and derivatives: develop from visceral layer of lateral plate mesoderm
- pupil, mammary and sweat glands: ectoderm
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How does the process of somite differentiation go?
- The ventral and medial part become mesenchymal, migrate around the neural tube and notochord (sclerotome)
- The dermamyotome forms
- Dorsomedial and ventrolateral cells become muscle cells
- The cells migrate medial and ventral
Which trancription factors play a crucial role in this process of somite differentiation?
- At the dorsomedial side, there are medium levels of BMP4 and high levels of Wnt
- At the ventrolateral side, there are high levels of BMP4 and medium levels of Wnt
What does the gradient of BMP4 and Shh also induce?
What are PAX genes important for?
- Development of dermatome
What is the role of Shh and FGF in somite differentiation?
- which cause the ventral part of the somite to become sclerotome
What is the role of PAX3 in somite differentiation?
What is the role of MYG5 in somite differentiation?
What is the role of MYOD in somite differentiation?
Why is there a split and combine in the sclerotome formation?
What does each somite induces?
How many sclerotome fuse in this process, and how many vertebrae are formed with this process?
- 7x vertebrae after
What does the notochord contribute to?
What kind of division can be made between the thoracic ribs?
- True ribs (1-7) connect to the sternum via their own cartilage
- False ribs (8-10) attach to the sternum via cartilage of other ribs
- Floating ribs (11-12) do not connect to the sternum
How is proved that cell fate in the to-be rib cells is already determined?
What are the three categories of defects on the spinal vertebrae?
- Congenital: process of splitting and fusion went wrong
- Idiopathic: unknown origin
- Neuromuscular: as a result of another disease
What nerves that run through the openings in the vertebrae innervate the muscles?
What are the peripheral nerves that pass through the openings of the vertebrae?
Why are the dorsal root ganglia not considered part of the CNS?
What are the two components of the skull?
- The neurocranium
- The viscerocranium
picture: viscerocranium
What does the neurocranium consist of?
- Membranous part (flat bones that surround the brain)
- Cartilaginous part (forms bones of) the base of the skull
What does the membranous neurocranium consist of?
- Neural crest cells
- Paraxial mesoderm
Mesenchym from neural crest cells and paraxial mesoderm undergo ossification without making cartilage.
What is the membranous neurocranium typified by?
How does the cartilaginous neurocranium form?
What does the growth of the skull depend on?
How are the separate flat bones of the skull connected to each other?
Where are the bones of the face formed from?
What are the three structures that form from the first two pharyngeal arches and give rise to the face?
- Mandibular prominence
- Maxillary prominence
- Nasal prominence
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