Development of the brain - II

35 important questions on Development of the brain - II

What are the three layers of the meninges (meningeal coverings)?

  • Dura mater
  • Arachnoid mater
  • Pia mater

In what space does the cerebrospinal fluid exist?

In the subarachnoid space (between the arachnoid mater and the pia mater)

What is the problem in children with hydrocephaly?

There is blocked circulation of CSF (cerebrospinal fluid), usually in the cerebral aqueduct, which causes growth of the skull
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What does the mnemonic 'Tel Die Messen Met My' stand for?

  • Tel: Telencephalon, and Die: Diencephalon > forebrain
  • Mes: Mesencephalon > midbrain
  • Met: Metencephalon, My: Myencephalon > hindbrain

How does the development of the brain start?

With rhombomeres, which induce neuronal crest cells to form the pharyngeal arches, and also express Hox genes.

Which rhombomeres form into the myencephalon, and what structure does it become?

Rhombomeres 3-8, they give rise to the medulla oblongata

Which rhombomeres give rise to the metencephalon, and what structure does it become?

Rhombomeres 1-2, they become the cerebellum and pons

What is cerebellar medulloblastoma, and how does it spread?

- Childhood cancer in cerebellum with fetal origin
- Spreads through CSF to other parts of the brain

Which two systems are part of voluntary action?

  • Afferent system: receptors/sensory fibers bring info to CNS
  • Efferent system: effectors bring info from CNS to muscles

What did sensory neurons develop from?

They grew out from neural crest cells as dorsal root ganglia

Why are the sensory neurons or dorsal root ganglia considered to be part of the PNS?

Their cell bodies are outside of the vertebral column

How is the part at the ventral side of the spinal cord called, and what kind of neurons can be found there?

The basal plate, where the motor neurons are located.
(SAMBa)

The spinal cord is structured in different areas, so with an alar plate and a basal plate. What is also structured in this way?

The brain

How is this division of alar plate and basal plate visible in the development of the rhombencephalon?

The sensory neurons start to develop at the alar plate, but then move down to the basal plate position.

What is the red nucleus of the mesencephalon?

- A part in the mesencephalon that is believed to be red because of the hemoglobin and ferritin
- It functions as an additional motor pathway

What is the clinical significance of the substantia nigra, another part of the mesencephalon?

(- black because of neuromelanin)
- In Parkinson's disease, this is the part of neuronal loss

What part of the mesencephalon receives axons from the retinae, and what does this part contain?

- The Superior Colliculus,
- which also mediates ocular reflexes, it contains a 2D map representing half of the visual field

What part of the mesencephalon gets input from the cochlea

The inferior colliculus, which also mediates auditory reflexes.

What happens when SC development is inhibited by, for example, a teratogen?

Aberrant sensory processing

What are the three types of cortical areas in the telencephalon?

  • Primary motor areas
  • Primary sensory areas
  • Association areas: interpreting sensory input and putting together a motor response

Where is the cerebral cortex located?

The outermost layer of the gray matter, it makes up the superficial layer of the cerebrum

What can be visible in the cerebral cortex from all the body parts?

The body parts literally have a space in the primary motor cortex and/or the primary sensory cortex.

What are the three integrative centers of the cortex?

  • General interpretive center (Wernicke's area) (combines information from different areas)
  • Speech center (Broca's area) (muscle movement and breath patterns involved in speech)
  • Prefrontal cortex (higher cognitive functions)

What are 3 disorders of the association cortex, and what areas are involved?

  • Agnosia: inability to recognize familiar objects (problem in association areas)
  • Apraxia: normal muscle function, but inability to execute voluntary movements (problem in motor and premotor areas)
  • Aphasia: problems in language comprehension and production (problem in Broca's and Wernicke's area)

What is prefrontal cortex dysfunction involved in?

  • ADHD
  • Addiction
  • Schizophrenia

What are the 4 main parts of the telencephalon or cerebrum?

  • Cerebral cortex
  • Hippocampus
  • Basal ganglia
  • Olfactory bulb

What is the function of the basal nuclei (or basal ganglia)?

The major part is the striatum, which functions in motor initiation.
Functions:
  • Communication with diencephalon
  • Receiving input from dopaminergic neurons of the mesencephalon (play a role in Parkinson's disease)

What is the role of basal nuclei in voluntary movement?

They do not initiate volunatary movement, but they provide subconscious control of muscle tone (coordination)

What are 3 diseases in which a problem in the basal nuclei plays a major role?

  • Huntington's disease (loss of neurons in striatum)
  • Hemibalism (CVA)
  • Parkinson's disease (slowness of movement, loss of neurons in substantia nigra)

What are the two areas of the telencephalon that play a role in memory and emotional expression?

The hippocampus and the amygdala

When does the amygdala get activated, and what suppresses this reaction?

- Amygdala gets activated when seeing frightful faces or scenes
- Suppressed by oxytocin

What 3 diseases are a result of a problem in the limbic system?

  • Autism (problem in expressing emotion and affection)
  • Urbach-Wiethe (inability to express fear)
  • Alzheimer's disease (memory loss)

What are 3 glands that belong to the diencephalon?

  • Pineal gland (melatonin production, light sensing, sleep rythm)
  • Hypothalamus
  • Pituitary gland

What are functions of the hypothalamus?

  • Regulate cardiac and smooth muscles, endocrine systems
  • Goal-directed behaviour
  • Hunger, thirst
  • Body temperature
  • Hormone secretion

How can you summarize the functions of the forebrain, midbrain and hindbrain?

Forebrain: 'all what we believe we are'
Midbrain: sensing and moving
Hindbrain: integration of info

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