Plasticity and hormonal influence of the brain

25 important questions on Plasticity and hormonal influence of the brain

What 3 kind of signal circuits are 'tuned' in a baby before it is born?

- Motor circuits: by moving limbs
- Visual circuits: systematic moving patterns
- Auditory circuits: child has preference for native language immediately after being born

When something in the motor, visual or auditory circuit is not right after the child is born, what is important to take into account for the treatment?

That these circuits have a critical period for developing (for example, amblyopia)

What shows that nurture in the development of visual, auditory and motor circuits is very important?

The fact that the brain is very active during the first 10 years of life.
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From a phylogenetic point of view, what parts of the brain mature first?

Phylogenetically the oldest regions of the brain mature first, and the higher-order areas mature last.

To what extent is the brain plastic, and how does it make new connections and pathways?

It has a huge ability to reorganize itself, and new connections are made through practice.

What does the brain do after damage or injury?

Undamaged neurons start to make new connections and take over functions, it also responds to important experiences (blind people have very developed other areas)

When in your life is the most 'optimal' time to get brain damage, as regards to brain plasticity?

The younger the better.

What are possible causes of brain damage?

  • Tumor
  • Infection
  • Toxic substances
  • Degenerative disease
  • Cardiac arrest

What are two different types of strokes, and what kind of problems do they cause?

  • Ischemia: blood clot/obstruction of an artery, so that neurons lose their oxygen and glucose supply
  • Hemorrhage: ruptured artery, which causes neurons to have an excess of calcium, oxygen, and other nutrients

To what extent can people that suffer from brain damage recover?

They often show behavioural recovery, and the mechanisms of recovery can resemble the mechanisms of brain development, however, often not the right type of connections are made.

What technique is often used to help the brain recover, and what are the side effects of it?

- Deep brain stimulation (DBS), in which neurons are stimulated (it is not known how it works),
- there can be 'damage', for example depression and personality changes

Why is partial brain damage informative?

You can learn more about the function of that specific brain structure.

What causes the male and female brain to become different in fetal development?

Sex hormones early in development produce anatomical and physiological differences

What is the sexually dimorphic nucleus?

An area in the anterior hypothalamus that is larger in males and plays a role in controlling male sexual behaviour.

What two factors cause males and females to exhibit sex differences?

  • They secrete different hormones, AND
  • these hormones are acting on a sexually dimorphic brain

Sex hormones during fetal development are critical for the development of a sexually dimorphic brain, but what do sex hormones postnatally effect?

These hormones are necessary for the right behaviour.

How does testosterone in males cause the development of a 'male' brain?

- Testosterone is secreted into the blood and reaches the brain
- Testosterone is converted into estradiol and DHT
- Estradiol masculizes the brain

What are the two hypotheses on the role of estrogens in female brain development?

  • Hypothesis 0: Alpha-fetoprotein transports estrogen to specific sites in the brain where it is involved in processes (feminization?)
  • Hypothesis 1: Alpha-fetoprotein protects estrogens from travelling into the brain (because estrogens cause masculinization)

Which hypothesis is experimentally proven to be correct?

Hypothesis 1 (so Alpha-fetoprotein protects estrogens from entering the brain).

What is the postnatal role of estradiol in the female brain?

It feminizes the brain.

What is the function of the Medial preoptic area (MPA) in males?

It plays an important role in male sexual behaviour.

Which site in the brain is also important in male sexual behaviour, and how does this differ between males and females?

- bNST
- is around 2.5x larger in males

What is the function of bNST?

It projects to the MPA with chemosensory information, and seems to play a role in transsexual men

According to recent studies, what is the most important factor in gender identity?

Not so much rearing and experience (so it is not learned by the surroundings), but biological factors, especially prenatal hormones, play a large role in gender identity.

Besides these hormones, what are three things that can play a major role in behavioural differences between males and females?

  • Confidence
  • Cultural differences
  • Education

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