Lympocytes - B-cells - B-cell development
5 important questions on Lympocytes - B-cells - B-cell development
What are the five stages of B-cell development?
- Interaction between stromal cell and precursor B cells (VCAM-1/VLA-4 and CAMs)
2. Early pro-B cell
- Upregulation of Kit (CD117) and binding to SCF (stem-cell factor)
3. Late pro-B cell
- Pro-B cell proliferates
4. Pre B-cell
- Expression of pre-B cell receptor
5. Immature B cell
- B-lineage cells move towards the central axis of the marrow cavity
In which stage of B-cell development is IgM first expressed?
When does V-DJ rearranging in the H-chains genes take place in B cell development?
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What kind of selection takes place between the immature and mature stage of B-cells
What are the definitve B cell lineage markers?
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