Lympocytes - B-cells - B-cell development

5 important questions on Lympocytes - B-cells - B-cell development

What are the five stages of B-cell development?

1. Committed lymphoid progenitor
- Interaction between stromal cell and precursor B cells (VCAM-1/VLA-4 and CAMs)
2. Early pro-B cell
- Upregulation of Kit (CD117) and binding to SCF (stem-cell factor)
3. Late pro-B cell
- Pro-B cell proliferates
4. Pre B-cell
- Expression of pre-B cell receptor
5. Immature B cell    
- B-lineage cells move towards the central axis of the marrow cavity

In which stage of B-cell development is IgM first expressed?

Immature B-cell. On cell surface

When does V-DJ rearranging in the H-chains genes take place in B cell development?

In the late pro-B cell stage
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What kind of selection takes place between the immature and mature stage of B-cells

Selection for self tolerance and productive gene rearrangement. If the cell survives, it will become a mature (or naïve) B cell that makes IgM and IgD

What are the definitve B cell lineage markers?

Immunoglobulins, IgM and IgD

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