General - Mucosal immunity

9 important questions on General - Mucosal immunity

Which percentage of immune cells can be found in the gut?

Up to 70%

What are the characteristics of the colon?

- No villi, but a flat surface epithelium
- Crypts are larger
- No Peyer's patches but diffuse lymphoid aggregates

What in gut mucosal immunity is part of the innate response?

- Epithelial surface: Paneth cells, goblet cells, mast cells, epithelial cells, gamma delta IELs
- Lamina propria: Macrophages, dendritic cells, granulocytes
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What in gut mucosal immunity is part of the adaptive response?

Lamina propria, Peyer's patches, MLN, lymphoid aggregates: B cells, T cells

What is the function of M cells?

Transport of antigen from lumen to lymphoid areas

What is the function of dendritic cells in gut mucosal immunity?

Extend dendrites between epithelial cells in order to sample adherent bacterial species

What is the function of Paneth cells in gut mucosal immunity?

Secrete antimicrobial peptides

What is the function of mucosal mast cells in gut mucosal immunity?

Secrete enzymes and mediators

Which cell types are present in gut epithelial and what is their function?

- Enterocytes (absorption)
- Enteroendocrine cells (hormones, interactions with nerves)
- M cells (antigen transport)
- Goblet cells (mucus production)
- Paneth cells (antimicrobial peptide)

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