The lymphoid system - Common lymphoid progenitor - NK cells

4 important questions on The lymphoid system - Common lymphoid progenitor - NK cells

What do NK cells lack?

NK cells lack antigen-specific receptors, but can recognise tumour cells and cells infected with viruses

What do NK cells look like?

-Larger cells
- More cytoplasm
- More cytoplasmic granules

What is ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity)

Recognition of  Ig on infected cells by CD16 on NK cells results in activation of NK cells, release of cytolytic granules, kills cells by apoptosis
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Why are NK cells key players in eliminating and preventing tumour growth?

1. Formation of conjugate between NK and tumour cells
2. Release of cytolytic granules

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