RNA virus - Filoviridae - Ebolavirus

3 important questions on RNA virus - Filoviridae - Ebolavirus

What are the clinical features of Ebola?

- Fever
- Malaise
- Muscle aches
- Respiratory symptoms
- Diarrhoea
- Vomiting
- Epistaxis
- Haemoptysis
- Haematemesis
- Rash
- Tremors
- Sub-conjunctival haemorrhages
- Fluid distribution problems
- Hypotension
- Coagulation disorders
- Bleeding tendency
- Fulminating shock

How is Ebola transmitted to humans?

- Direct contact
- Break in skin
- Mucosa
--> Eyes very susceptible

What is the primary target cell of Ebola?

Mononuclear phagocytes

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