Clinical immunology - Allergy
7 important questions on Clinical immunology - Allergy
What is type I hypersensitivity and what is the mechanism behind it?
Name some examples of a type I hypersensitivity reaction
- Asthma
- Systemic anaphylaxis
What is type II hypersensitivity and what is the mechanism behind it?
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Name some examples of type II hypersensitivity reactions?
- Transfusion reaction
- Autoimmune haemolytic anaemia
- Graves disease
- Myasthenia gravis
Name some examples of a type III hypersensitivity reaction
- Systemic lupus erythematosus
What is type IV hypersensitivity and what is the mechanism behind it?
1. CD4+ (delayed-type hypersensitivity), tissue injury occurs due to macrophage activation and cytokine-mediated inflammation
2. CD8+ CTLs (T cell mediated cytolysis), tissue injury occurs due to direct target cell lysis, and cytokine mediated inflammation.
Name some examples of type IV hypersensitivity reactions
- Graft rejection
- Rheumatoid arthritis
- Diabetes mellitus
- Asthma
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