Immune evasion
7 important questions on Immune evasion
In which ways do pathogens evade the innate immune system?
2. Physical structures which prevent recognition
3. Immune-privileged tissues
4. Evasion of cell mediated innate recognition
5. Active inhibition of phagocytosis
6. Intracellular survival strategies
7. Evasion of autophagy
In which way do pathogens evade the adaptive immune system?
2. Evasion of T cell activation
3. Subversion of cytokines and chemokines
4. Manipulating the regulation of immunity
5. Evasion of antibody mediated immunity
6. Change the antigens
What is an immune privileged site?
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Why do we have immune privileged sites?
Name the immune privileged sites
- Brain
- Testes
- Placenta
- Foetus
Which explanations have been given to the presence of these immune privileged sites?
- few dendritic cells
- little lymphatic drainage
- presence of soluble immune inhibitors (TGFb)
- presence of cell-bound inhibitors (CD200, FasL, PD-1)
What is one of the issues of immune privileged sites?
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