Immune evasion

7 important questions on Immune evasion

In which ways do pathogens evade the innate immune system?

1. Evasion of complement
2. Physical structures which prevent recognition
3. Immune-privileged tissues
4. Evasion of cell mediated innate recognition 
5. Active inhibition of phagocytosis
6. Intracellular survival strategies
7. Evasion of autophagy

In which way do pathogens evade the adaptive immune system?

1. Interference with macrophage/DC functions
2. Evasion of T cell activation
3. Subversion of cytokines and chemokines
4. Manipulating the regulation of immunity
5. Evasion of antibody mediated immunity
6. Change the antigens

What is an immune privileged site?

The lack of immune responses in tissue.
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Why do we have immune privileged sites?

Because immune response and its associated inflammation can cause lethal organ dysfunction or reproductive failure in certain organs.

Name the immune privileged sites

- Eye
- Brain
- Testes
- Placenta
- Foetus

Which explanations have been given to the presence of these immune privileged sites?

- tissue-blood barrier
- few dendritic cells
- little lymphatic drainage
- presence of soluble immune inhibitors (TGFb)
- presence of cell-bound inhibitors (CD200, FasL, PD-1)

What is one of the issues of immune privileged sites?

They are great tissue reservoirs for viral persistance

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