The development of T lymphocytes - The HLA-system
3 important questions on The development of T lymphocytes - The HLA-system
What is the peptide binding motif?
- combination of anchor residues is the peptide binding motif
- this motif dictates whether a peptide will bind in the respective HLA
- all peptides with this motif can be presented by te HLA-molecule
- HLA allotypes with overlapping anchor residues in this motif can bind overlapping peptides
- this motif dictates whether a peptide will bind in the respective HLA
- all peptides with this motif can be presented by te HLA-molecule
- HLA allotypes with overlapping anchor residues in this motif can bind overlapping peptides
How many HLA isotypes are recognized by T cells?
3 for both MHC I and MHC II
How many peptides can an MHC molecule present?
Many thousands, this is promiscuous specificity
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