Antigen recognition by T lymphocytes - T cell receptor

3 important questions on Antigen recognition by T lymphocytes - T cell receptor

What mechanism ensures we have many different T cells and a broad repertoire of TCR?

The TCR resembles the antibody Fab fragment, though is membrane bound

What are the antigen binding site?

- formed by the variable region V of both the TCR alpha and TCR beta
- specific for a single TCR
- specific for recognition of one epitope

What is somatic recombination?

Cutting an pasting TCR DNA

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