The role of the immune system in learning, memory, neural plasticity and neurogensis under quiescent conditions - The role of the immune system in promoting learning and memory - The role of T cells

5 important questions on The role of the immune system in learning, memory, neural plasticity and neurogensis under quiescent conditions - The role of the immune system in promoting learning and memory - The role of T cells

What is the idea about T cells that are reactive to CNS auto-antigens?

They boost learning and memory in rodents.

Where do the T cells that interact the most with the brain reside?

In the meningeal spaces, depletion of meningeal T-cells resulted in memory and learning impairments (Derecki et al., 2010)

By which means do T cells in the meningeal space supportively interact with the brain?

By releasing IL-4 (Derecki et al., 2010)
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What is the main idea of this paragraph?

Properly functional and regulated T cell activity is a necessity in healthy cognitive functioning.

How can T cell activity be boosted?

  • physical exercise (Ron-Harel and Schwartz, 2009)
  • calorie restriction
  • vaccination with a weak CNS auto-antigen

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