The role of the immune system in learning, memory, neural plasticity and neurogenesis under inflammatory conditions - Detrimental effects of immune/inflammatory processes on neurogenesis
3 important questions on The role of the immune system in learning, memory, neural plasticity and neurogenesis under inflammatory conditions - Detrimental effects of immune/inflammatory processes on neurogenesis
What do they say about chronically activated microglia?
Their ability to produce pro-inflammatory cytokines is reduced (Bonde et al., 2006).
What is the role of the fractalkine axis on microglial activation status?
Fractalkine signalling keeps microglia in a quiescent state.
Which cytokine is most suppressive of neurogenesis in high levels?
IL-1
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