The role of the immune system in learning, memory, neural plasticity and neurogensis under quiescent conditions - The role of the immune system and inflammatory cytokines in neurogenesis

5 important questions on The role of the immune system in learning, memory, neural plasticity and neurogensis under quiescent conditions - The role of the immune system and inflammatory cytokines in neurogenesis

What are physical exercise and enriched environments associated with?

increased memory and increased neurogenesis.

What is the initial evidence in the role of T cells in neurogenesis?

The finding that T cell derived IL-4 and low levels of IFN-g can activate microglia to promote neurogenesis in vitro (Butovski, 2006)
AND
T cell replenishment in T cell deficient mice restores impaired neurogenesis in the hippocampus (Ziv et al., 2006)

Which specific T cell type seems to be involved in support of neurogenesis?

The T CD4 cell (Wolf et al., 2009)
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What was the first notion that microglia play an protective and supportive role in neurogenesis?

Mice held in an enriched environment showed increased neurogenesis and an increased in microglia number.

What is said about the interaction between T cells and microglia involving neurogenesis?

The influence of microglia on neurogenesis may be related to their interactions with T cells, since in transgenic mice with excess  CNS-specific T cells the increased neurogenesis was attenuated by the microglia inhibitor minocycline (Ziv et al., 2006).

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