Viral and CD4+ T cells in HIV infection
6 important questions on Viral and CD4+ T cells in HIV infection
What is the hallmark of an HIV-1 infection regarding the immune system? Why is this a problem if you are infected?
Is the HIV virus latent? If not, why is it still a problem?
The main problem now is the during treatment the level on virions is kept low, but the patients will keep a latent level of infected cells.
Why can't HIV-induced cytopathicity be a cause of CD4+ T cell loss? (pathological changes in cells)
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Telomere shortening can be seen as a marker of replicative history of T cells (also associated with cell senescence). Then why is it weird that naive and memory T cell telomeric length decline parallel? And are CD4+ T cell telomeres shortening more rapidly than the HIV infection is dividing?
No, CD8+ T cells showed stronger telomeric loss but not CD4+ T cells. Therefore telomeric length can't be used as marker for loss of CD4+ T cells in HIV infections, thus is not the cause of this loss.
How can the thymic output be measured? What was seen for this in and HIV infection?
At the moment what seems to be the cause for CD4+ T ceell loss with an HIV infection and how does this work?
homeostatic response to T cell depletion, but reflects persistent activation of the immune system
High immune response leads to AIDS state (high level of CD70)
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