Cell-mediated Imunnity
6 important questions on Cell-mediated Imunnity
How do T cells get activated by dendritic cells?
What various pathways can be used by DCs to process and present degraded antigen proteins?
1. Receptor-mediated endocytosis of bacteria (CD4 T cell) --> via vesicle/endosome
2. Macropinocytosis of bacteria or viruses (CD4 T cell) --> via vesicle/endosome
3. Viral infection (CD8 T cell) --> via ER
4. Cross-presentation of exogenous viral antigens (CD8 T cell) --> via ER
How do naive T cells home to the secondary lymphoid tissues?
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After naiev T cell activation effector T cells are formed by the cytokine enviroment. What type of T-helper cells are there?
- TH1: activates macrophages to become highly microbicidal: intravesicular bacteria are killed by the activated macrophage
- TH2: activate cellular and antibody response to parasites
- TH17: enhance neutrophil response
- TFH: activate B cells to refine the antibody response --> Tfh and naïve B cell that they help, recognize different epitopes of the same antigen
- Treg: suppress other effector T cells --> suppression of autoreactive T cells by Treg needs both T cells to engage the same antigen-presenting cell
What would be the expected phenotype of people who have no functional AIRE?
Why is there a big difference in thymocyte numbers observed when comparing TCRα-/- to TCRβ-/- thymocytes?
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