A selective sweep in chimpanzees
4 important questions on A selective sweep in chimpanzees
What is the difference between the binding of MHC class I and class II?
How can chimpanzees still get AIDS when they don't seem to have an immune response?
Why are chimpanzees relatively resistant to AIDS?
- Chimpanzees experienced a selective sweep affecting the MHC class I gene repertoire, approximately 2-3 myr, as was illustrated by intron 2 analysis
- Chimpanzees only have MICB and not MICA that humans do have are the best lead for fighting the HIV infection displaying limited polymorphism
Hypothesis: The MHC class I repertoire reduction in chimpanzees may have been caused by an HIV-1/SIV like retrovirus
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What was the conclusion of the study in which they investigated whether the selective sweep was possibly caused by HIV-1/SIV and has resulted in the preferential selection of Patr class I molecules that are like AIDS-resistant molecules in human individuals, such as HLA-B*27/B*57? What is a selective sweep?
Selective sweep: recombination of genes that give different phenotypes but selected on a specific characteristic
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