Summary: Immunology
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Lecture 1
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How do pathogens come into the body? Why via these tissues?
Via mucosal tissues because these tissues are very permeable. -
What are examples of mucosal tissues?
- Respiratory tract
- Urogenital tract
- Gastrointestinal tract
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What are two different classifications of pathogens?
- Intracellular
- Extracellular
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What immune cells belong to the innate immune system?
- Granulocytes (short life cycle)
- Macrophage
- Neutrophils
- NK cells
- Complement
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What is the difference between granulocytes and macrophages?
Granulocytes kill bacteria and macrophages 'eat' big particles. -
What does CD mean in CD4 and CD8?
Cluster of deviation -
When do you speak of a disturbed immune system?
- Autoimmune diseases (against 'self')
- Allergies
These are both immune responses against harmless things. -
What is so special about the immune system?
The immune system is a balance between activation and inactivation (immunity vs tolerance). -
How can you artificially induce immune responses?
- Vaccination
- Anti-tumor therapy
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What are the three levels of protection?
- Barriers: skin, mucous, membranes, chemicals
- Innate immune response: immediate response, fast, not specific
- Adaptive immune response: slow to be activated, very specific
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