Tolerance - B-cell tolerance - pheripheral
3 important questions on Tolerance - B-cell tolerance - pheripheral
Why do transitional B cells enter the periphery (follicles in spleen)?
In this place the maturation continues, there they encounter antigens and other immune cells that can activate them into further development and activation and therefore the B-cells can undergo further differentiation into a specific mature B cell depending on the antigens they encounter. Because some antigens are tissue specific and therefore require the right antigens.
Why is there a second round of selection for B-cells in the spleen?
Because some antigens are tissue specific
What happens to the B-cells that will react to strongly to tissue specific antigens?
All the cells that will transfer to the spleen an are still auto reactive will die
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