Autoimmunity

7 important questions on Autoimmunity

Why are tolerance and autoimmunity so closely related?

The failure or breakdown of immunological tolerance results in autoimmunity and autoimmune disease.

What is the difference between auto-inflammatory and autoimmunity?

Autoinflammatory is the dysregulation of the innate immune system while autoimmunity an inappropriate adaptive immune response is.

What is thought to be the reason of autoimmunity?

A combination of genetic susceptibility, breakdown in natural tolerance mechanism and environmental triggers, but a disease develops only if enough safeguards are overcome to lead to a sustained reaction to self.
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Can body take any precautions while immune system is developing such that these autoreactive cells are not produced?

This is done by immune tolerance that works like a safeguard mechanism to prevent the production of autoreactive cells.

How can a B-cell damage the tissue?

1. Circulation B cell binds to self-antigens that are released from injured cells.
2. When the B cell is activated by a T-cell specific for the self-peptide the B cell differentiate into plasma cells
3. These cells secrete a large amount of self-antigen specific antibodies.
4. At the site of the injury, the self-antigen specific antibodies initiate an inflammatory response which cause more cell injuries.
5. More B cells bind to the antigens, and this amplified the cycles and the tissue damage.

What is a clue that genetics plays a role in autoimmune diseases?

That there is a difference in incidence of autoimmune disease between men and women. Many autoimmune diseases are more common in females than in males.

What are immunologically privileged sites and some examples in the body?

The brain, eye, testis, and uterus are some examples from the privilege’s sites. These places do not have immunity.

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