Tumorimmunity - Tumor developement

4 important questions on Tumorimmunity - Tumor developement

How do tumor cells develop?

1. When tumor arise in a tissue, several immune cells can recognize an eliminate them.
2. Variant tumor cells arise that are more resistant to being killed.
3. Over time a variety of different tumor variants develop
4. Eventually one variant may escape the killing mechanism or recruit regulatory cells to protect it and so spread unchallenged.

How do NK cells recognize tumors?

NK cells recognize stressed cells, tumor cells are stressed cells and thus will express ligands that NK will recognize.

When do you have an increased risk of cancer?

People with diminished immune system function have an increased cancer risk: Primary immunodeficiencies, organ transplant recipients, HIV patients.
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Why do people of organ transplant recipients have an increased risk of cancer?

This is because they take immunosuppressant medicines and thus tumors can escape easily.

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