Tolerance - T-cell tolerance - Pheriperal
10 important questions on Tolerance - T-cell tolerance - Pheriperal
How can you recognize the Tregs?
What is regulatory tolerance?
How to Tregs suppress self-reactive lymphocytes?
o Cytolysis: Kill activated T-cells
o Metabolic regulation: consume nutrients that other immune cells needed to be activated so that they can’t be activated. (IL-2 consumption)
o Modulate the DC maturation and function: prevent activation of other cells and promote tolerance.
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What is the difference between nTregs and iTregs?
How are natural Tregs formed?
How does Foxp3 block the production of IL-2?
Why do Treg cells stop to production of IL2?
What is the role of CD25 expression on Treg cells?
How does CTLA-4 expression on Treg cells contribute to their inhibitory function?
What is the function of IL10?
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