Tumorimmunity - evading the immune system
4 important questions on Tumorimmunity - evading the immune system
How can tumor evade the immune system
2. Tumor antigen is tolerated as a self-antigen.
immune cells are not activated.
3. Tumor may lose or mutate the tumor antigen.
4. Tumor induces immune suppression.
5. Tumor cells create a physical barrier for immune system.
In which three ways can tumor evade the immune system by tumor-induced immune suppression?
o Attraction of Treg cells and this influence the activation of Th1 or other T-cells that can eliminate the tumor.
o Tumor cells express PD-L1 that binds to the inhibitory receptor PD-1 on T cells that inhibit the activation of the T-cells.
How does the creating of the physical barrier protects the tumor cell?
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How does the toleration of the tumor antigen protect the tumor?
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