Immunity to microbes (Huckriede)
15 important questions on Immunity to microbes (Huckriede)
What is the pathogenic mechanism of extracellular bacteria?
- Induction of inflammation
What are the receptors sensing bacterial infections? (Signalling and endocytotic receptors?
Endocytic receptors: C-type lectin-like receptors, scavenger receptors, N-formyl met-leu-phe receptors
What mechanisms drive the innate immunity to extracellular bacteria?
+ Innate lymphoid cells
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What are the important inflammatory cytokines produced by macrophages, mast cells and endothelial/epithelial cells?
What accumulates during local inflammation?
Complement activation -> Effector cells
By what is the alternative pathway and lectin pathway activated?
Lectin pathway: Mannose-binding lectin
The complement system. What does C3a, C3b, and C5a induce?
C3b: Opsonization and phagocytosis
C5a: Inflammation
What does the C-reactive protein test screen for?
What is the adaptive response to extracellular bacteria?
- activation of CD4+ helpter T cells
What does an CD4+ helper T cell produce to activate macrophages?
How do super antigens cause a cytokine storm?
What is the pathogenic mechanism of intracellular bacteria?
- induction of epigenetic changes leading to gene silencing or activation
Which receptors sense infections by intracellular bacteria?
Which cells are involved in innate immunity to intracellular bacteria?
- Phagocytes
- Type I ILCs
What is the adaptive response to intracellular bacteria?
The question on the page originate from the summary of the following study material:
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