Parasites
15 important questions on Parasites
What is the life cycle of echinococcosis granulosus?
What is the life cycle of echinococcosis multilocularis?
What are negative effects of a helminth infection?
- Susceptible to infections due to reduced immunity
- Tumors, probably of reduced anti-tumor immunity
- Reduced vaccine efficacy due to reduced immune response
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What are positive effects of a helminth infection?
- Prevents allergies/asthma
- Prevents auto-immune diseases
- Reduced incidence of inflammatory bowel diseases
Which three types of parasites are there?
- protozoa
- arthropods (exoskeleton, spider/tyke)
How is Schistosomaisis treated?
What are CAA and CCA?
After 4-6 weeks CAA and CCA can be detected
How is malaria treated?
Why is it difficult to design a vaccine against parasites?
- they develop quickly to other stages which makes it difficult to generate a proper immune response towards one life stage
- parasites are very good at evading the immune system
Why is it difficult to design a vaccine against hiv?
- no complete understanding of the immune response
- limited investments
Which type of immune response is provoked by parasites?
Explain antigenic diversity and antigenic variation
Variation = multiple copies of one gene in an organism
Explain the life cycle of Cysticercosis
Worms have both female and male organs (hemaphrodite) and they release small peaces of their tail that are excreted via the stool. These small pieces break open in the environment, which releases eggs.
Explain the life cycle of dracunculiasis
Through wich mechanism does pathology occur in malaria and schisto?
S: eggs can get stuck in capillaries and cause an immune response.
Secreted products (CCA and CAA) also provoke an immune response
The cercariae reside several days in the skin, which causes an inflammatory reaction -> skin rash
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