Chain of infection & categories of infectious disease agents

11 important questions on Chain of infection & categories of infectious disease agents

What is the life cycle of trichinella spiralis?

1. Larvae in pig
2. Larvae (L1) in human  
3. Maturation of larvae in small intestine
4. Reproduction
5. New larvae again in muscles in Nurse cells.

What is the life cycle of hookworm?

IMPORTANT: no jumping from species to species. So the hookworm in the soil was from humans.

1. Going through the skin (by walking barefoot); via teeth of the hookworm.
2. Go via the blood vessels to the heart and lungs.=> ophoesten => digestive tract
3. Maturing in the wall; steal your nutrients
4. Faecel in soil

Hygiene is really important

How long does it take for a hookworm larvae to generate new infective larvae? And how long can the worm live in our body?

2-3 months
years.
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What are symptoms of hookworm?

Anemia.
Retarded mental and physical development by children if not treated.

Which drug is availible?

Oral albendazole.

What determines the symptoms of schistosomiasis?

The amount of eggs and the location.
They can be in the liver, intestines, spleen, urinary tract and reproductive system.

What are the three types of schistosomiasis that cause infection in human?

S. Mansoni: intestinal
S. Haematobium: urogenital
S. Japonicum: intestinal

What is the pathology of schistosomiasis?

1. Toxin causes different symptoms.
2. The blood vessels erode
3. Irritation of the blood vessels => abscess and fibrosis around eggs => different inflammatory changes.
4. Itching at the side of enterance of the body
5. Hepatitis, dearrhoea, anaemia and eosinophilia => depends of where the eggs are.

What do we make as a reaction against schistosome eggs?

Granulomas; cyst like entities.
They lay around the parasites.

Granuloma itself is causing pathology in the host.

What is the epidemiology of schistomiasis?

200 million people wordwide
Neglected tropical diseases
Sub-Saharan Africa

What are fungi? Name two examples.

Nonmotile, filamentous organisms.
Very difficult to treat.

  1. Histoplasmosis: inhaling dust from soil. Bird droppings in the soil.
  2. Candidiasis:   

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