Chikungunda
8 important questions on Chikungunda
What kind of virus is the chikungunda virus?
- Enveloped positive sense RNA virus
- Glycoproteins with E1/E2 trimer
- Infusion mechanism with the envelop
- Infects mosquitoes and humans/vertebrate animals: evolutionary can keep matching in both hosts
- Infection in the mosquito is life-long (doesnt kill it)
- In human: arthritic symptoms => pain in the joints
What is the natural vertebrate host?
What are the symptoms of chikungunya?
- Rash
- Headache
- Swelling
- Joint pain
- Muscle pain
Most people feel better within a week. In others the pain stays for months.
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Where does the virus replicate?
- Midgut
- Salvia glands
- Ovaries
- Wings/legs of the mosquitoes
How can the virus replicate and survive in the human skin cells?
What is the pathogenesis of chikungunya in human?
- So virus is inside. Goes into dendritic cells (langerhans). Macrophagen (monocyten) replication.
- Lymphe nodes => dendritic cells present this to the T-cells
- Blood => viremia (sufficient amount for onward transmission by a mosquito bite)
- Liver, Spleen
- Muscle
Chronic arthritis => autoimmunity (cross reactivity => trigger to get it earlier?)
Where does chikungunya circulate?
Where does the virus spread towards?
- Joint pain and fever
1985: China
Viremic travellers brought it to new areas
- Spreading to Indian ocean region. (India etc)
The question on the page originate from the summary of the following study material:
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