Summary: Interleukin-6 And C-Reactive Protein, Successful Aging, And Mortality: The Polsenior Study
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Read the summary and the most important questions on Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
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1 Background
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What are the keywords of this study?
- immunosenescence
- Exercise
- IL-6
- CRP
- Aging
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What happens to the T and B cell population during aging?
The number of Naive T and B cells decreases with aging.
The number of memory and effector T and B cells increases with aging. -
What are the thought mechanisms behind inflammaging?
- Chronic viral infections (EBV, CMV)
- aging-related adiposity
- aging-related changes in the gut microbiota
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What are the measures of inflammaging?
A steady increase in pro-inflammatory markers like- IL-6
- TNF-a
- IL-1b
- CCL2
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What is the effect of pro-inflammatory cytokines on CRP levels?
They stimulate the synthesis of CRP in the liver. -
To which pathologies can elevated levels of pro-inflammatory cytokines and CRP lead?
All chronic diseases- Diabetes
- Neurodegenerative diseases
- Cancer
- Cardiovascular disease
- Frailty
- Stroke
- Sarcopenia
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What was the main aim of this study?
To investigate whether the results of a single measurement of IL-6 and CRP levels were associated with mortality in elderly participants of the PolSenior study who were followed for an average of 4.3 years, with a particular emphasis on individuals who had never been diagnosed with aging-related diseases and remained in good physical and cognitive health -
What were the secundary aims of this study?
- To determine possible associations between the concentrations of IL-6 and CRP and cognitive and physical functioning.
- Determine the effect of low-dose acetylsalicyclic acid on IL-6 and CRP levels
- To determine possible associations between the concentrations of IL-6 and CRP and cognitive and physical functioning.
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2 Methods
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2.2 Blood analysis
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Which blood molecules were investigated?
- IL-6 (serum; ELISA)
- CRP (serum, high-sensitivity immunoturbidymetric)
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What were the exclusion criteria based on blood samples?
- under treatment with glucocorticoids
- high leukocyte count
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