Infectious-Communicable diseases

26 important questions on Infectious-Communicable diseases

What is important to know about communicable diseases?

  • High burden of disease in LMICs
  • Disproportionately affect the poor
  • Enormous economic consequences
  • Burden of communicable disease is unnecessary (many can be prevented or treated)

What are infectious diseases, what are the characteristics?

Infectious diseases are also called communicable diseases, contagious diseases or transmissible diseases.
There are two main characteristics:
  • Caused by pathogenic micro-organism or an infectious agents (bacteria, virus, parasites, fungi)
  • Can spread, directly or indirectly, from animal to animal, animal to human, or human to human 

What are ways of classifying infectious diseases?

  • Pathogen
  • Transmission route
  • Infected organ
  • Setting
  • Prevention by vaccines
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What are the two types of transmission? What does it include?

  • Direct (physical contact, indirect contact, droplet spread)
  • Indirect (vector-borne, vehicle-borne, airborne)

Where do communicable diseases have a higher burden?

Communicable diseases are more prevalent in sub-Saharan Africa and south-east Asia.

What type of incidence fits malaria, cholera in Haïti, ebola in 2014, and H1N1 (influenza) in 2009?

Malaria: endemic (disease is always occurring)
Haïti: cholera outbreak, but affected the whole country so considered to be an epidemic
Ebola (2014): an epidemic because it affected one continent (West-Africa)
H1N1 (influenza) (2009): pandemic because it spread over the whole world

What are neglected tropical diseases (NTDs)?

Neglected tropical diseases (NTDs) are neglected diseases in tropical and sub-tropical countries. These diseases affect 1 billion people (especially people in poverty).

What are the challenges of NTDs?

  • Development of vaccines
  • Development of new drugs
  • Continuing in combating underlying risk

What is the difference between emerging and re-emerging diseases?

Emerging diseases are newly discovered diseases while re-emerging diseases are already existing diseases with an increasing burden or a new form.

What are factors that contribute to the emergence of infectious diseases?

  • Human demographics and behaviors
  • Advances in technology and industry
  • Economic development and changes in land use patterns (including effects of climate change)
  • Dramatic increases in international travel and commerce
  • Microbial adaptation and change
  • Breakdown of public health measures
  • Environmental changes

How are infectious diseases addressed?

  • Sensitive surveillance system for rapid detection of new outbreaks
  • Mechanisms for effective containment
  • Willingness to share information with other countries

What are challenges of infectious diseases?

  • Risk of major pandemic
  • Risk of accelerating drug resistance
  • Limited number of anti-effective drugs being developed

What are high burden infectious diseases?

  • HIV/AIDS
  • TB
  • Malaria
  • Diarrheal diseases

How to respond to infectious diseases?

  • Control of diseases
  • Elimination of disease
  • Eradication of disease
  • Extinction of disease

What is meant with control of disease?

Doing something to decrease the incidence, prevalence, mortality, etc to an accepted level.

What is meant with elimination of disease?

Elimination of disease means that the incidence is brought down to zero.

What is meant with eradication of disease?

Eradication of disease is termination of a disease and its transmission globally.

What is meant with extinction of disease?

Extinction means that specific infectious agents no longer exist in nature or lab.

What are the two conditions to eradicate a disease?

It must be an infectious disease (1) and there must be existing measures against the disease (2).

What are the five features to eradicate a disease?

  • Caused by only a small number of pathogens
  • Only one host
  • Visible and good diagnostics exist
  • Elimination has proven to be possible
  • Perceived disease burden is high

What are examples of control measures?

  • Vaccination
  • Mass chemotherapy (example: malaria pills)
  • Improve WASH (water, sanitation, hygiene)
  • Care seeking and detection
  • Case management and care improvement
  • Surveillance and monitoring
  • Behavioral change (example: cleaning hands, sexual education)

What is meant with antimicrobial resistance (AMR)?

Microorganisms change when they are exposed to antibiotics, as a result the medicine becomes ineffective, infections persist in the body and there is an increased risk of spreading infections.
This is an increasingly serious threat to global public health that requires action across all government sectors and society.
New resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases, resulting in prolonged illness, disability, and death.

What are reasons for AMR, how is it accelerated and how is the spread encouraged?

AMR happens naturally, it is because of adaptations to new situations.
It is accelerated by misuse and overuse of antibiotics for people and animals.
The spread of AMR is encouraged by poor infection control, inadequate sanitary conditions, and inappropriate food-handling.

What is the consequence of being sick as a child?

When you are sick as a child, you are not developing properly, there is a delay of entry into and performance at school, leading to lower productivity as an adult.

What is meant with the 90-90-90 goal of HIV/AIDS?

  • 90% of HIV-positives know their status
  • 90% of them is treated
  • 90% of those treated have suppressed viral loads

What is the mainstay to address TB?

DOTS: Directly Observed Therapy Short-course

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