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Motor control - Cerebellum

10 important questions on Motor control - Cerebellum

Where do the most corticofugal fibers go to?

The pons (and some to striatum and lower levels). From the pons the fibers are passed on to the cerebellum

Where do the corticofugal fibers go to from the pons?

To the cerebellar nuclei and cerebellar cortex (grey matter)

To what does the cerebellum project to?

A thalamic nuclei, only from the cerebellar nuclei and not from the cortex!
the thalamic nuclei projects back to the (pre)motor cortex

How many times are the fibers crossed over to the other side?

2 times, from the pons to the cerebellum and from the cerebellar nuclei to the thalamic nucleus

How is the tract that leaves from the (pre)motor cortex called?

The corticobulbospinal system

Which two types of afferent axons go to the cerebellum?

- mossy fiber axons

carry information to cerebellum from many sources
excitatory projection to central cerebellar nuclei and granule cells (=parallel fibers) in cerebellar cortex

many parallel fibers need to be activated to activate Purkinje cell

- climbing fiber axons

carry error-signal to cerebellum from inferior olivary nucleus
excitatory projection to central cerebellar nuclei and Purkinje cells in cerebellar cortex

one AP of climbing fiber is enough to activate Purkinje cell because the climbing fibers are tightly wrapped around Prukinje cells

How does error signaling work?

Climbing fiber AP will modify the strenght of parallel fiber synapses on Purkinje cell dendritic trees. This modifies the output of the cerebellar cortex.

Where do purkinje cells project to?

To the cerebellar nuclei, inhibitory

(mossy fibers also project to the cerebellar nuclei (and parallel fibers))

What is the difference between simple and complex spikes?

Simple = Purkinje cells stimulated by granule cells (parallel fibers)
- leads to typical AP if many are activated
Complex = Purkinje cells stimulated by climbing fibres
- leads to one broad atypical spike followed by a silent period

What happens if climbing and parallel fibers are active at the same time?

Hebb = fire together is not wire together
The strength of the parallel fiber is decreased by internalizing AMPA receptors (via PKC) --> long term depression

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Introduction into the neurosciences

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Motor control - Cerebellum

10 important questions on Motor control - Cerebellum

Where do the most corticofugal fibers go to?

Where do the corticofugal fibers go to from the pons?

To what does the cerebellum project to?

How many times are the fibers crossed over to the other side?

How is the tract that leaves from the (pre)motor cortex called?

Which two types of afferent axons go to the cerebellum?

How does error signaling work?

Where do purkinje cells project to?

What is the difference between simple and complex spikes?

What happens if climbing and parallel fibers are active at the same time?

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