Carboxylic Acids - What Is Fischer Esterification?
5 important questions on Carboxylic Acids - What Is Fischer Esterification?
What is Fischer esterification?
How can you predict the product of a Fischer esterification?
What are the six common mechanistic patterns for organic reactions?
2. Removal of a proton
3. Reaction between an electrophile and a nucleophile
4. Rearrangement of a bond
5. Breaking of a bond to form a stable ion or molecule
6. Collapse of a tetrahedral carbonyl addition intermediate to eject a leaving group and regenerate the carbonyl group.
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In a Fischer esterification H2SO4 is used as an acid catalyst, how will the sulfuric acid react with the alcohol?
What are the steps in the Fischer esterification mechanism?
2. Reaction between an electrophile (protonated carboxyl group) and a nucleophile (alcohol) to form an oxonium ion.
3. Removal of a proton from oxonium ion to an alcohol resulting in a tetrahedral carbonyl addition intermediate.
4. Addition of a proton to the hydroxyl group forming a good leaving group.
5. Collapse of the tetrahedral carbonyl addition intermediate, ejecting the leaving group and regenerating the carbonyl group.
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