Epigenetics and flavors of pluripotency - Extended pluripotency (Deng)

5 important questions on Epigenetics and flavors of pluripotency - Extended pluripotency (Deng)

Primed pluripotent state

The most commonly used pluripotent SC -> genetic instability is a major safety issue here

Naive pluripotent state

Major advantage is that there is no differentiation bias, can be used for gene targeting, high blastocyst chimeric potency, high developmental potential

Can we generate single-mEPS-cell-derived postnatal chimeric mice (showing both embryonic and extraembryonic chimerism)?

Yes. Higher chimeric efficiency compared to 2i-ESCs. High germline transmission efficiency.
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Why can EPS cells make extra-embryonic tissues?

There is an upregulation of a collection of genes that upregulate in embryonic cells early during preimplantation.

Gene editing of EPS cells

High gene targeting efficiency, high chimeric ability from edited cells and high success rate of tetraploid complementation (very fast process).

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