T cell homing and activation
4 important questions on T cell homing and activation
What happens when a T cell gets activated?
Normal, they are G0 stage en do not make any protein
- ATP from TCA cycle while lactaat from glycolysis
What does happen to IL-2 receptor when it is activated?
Activated T cell can screte or respond to IL-2, which enhanced proliferation and T cell differatation
How does Tcell attenuate TCR signaling?
- CTLA-4 binds to two B7 homodimer compared to CD28, has much higher affinity and outcompetes CD28 binding for B7
- CTLA-4 can be internalized with bound B7 removing B7 from APC surface
- CTLA-4 may transmits a negative signal that inhibit TCR signaling
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What is licensing of DC?
- CD8 T cells that recognize antigen on weakly co-stimulatory cells can become activated through CD4
- CD40 ligand expressed on CD4 can signal via CD40 on dc to up regulate expression of B7 and CD70 to stimulate naive CD8 and increase production of il-2 in APC
The question on the page originate from the summary of the following study material:
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