Mucosal Immunity and Innate Lymphoid Cells
3 important questions on Mucosal Immunity and Innate Lymphoid Cells
How is tolerance in Galt made?
Antigen delivered to GALT, which induce FoxP3+ Treg cells, therefore retinoid acid and TFG-b is needed to induce Treg differentiation
Difference between intestinal DC and peripheral DC
- In GALT, the lines between migratory and lymphoid tissue-resident DC are blurred
- In TGF-b rich microenvironment, Intestinal DC induce noninflammatory adaptive responses dominated by production of Treg cell and Tfh that favor B class switching to secretory IgA
Routes for antigen uptake
- Bulk and receptor-mediated transport across M cells
- FcRn-dependent transport
- uptake via goblet cells
- paracellulaire transport across tight junctions
- apoptosis-dependent transfer
- antigen capture by TEDs
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