Evade innate IS / phagocytosis

5 important questions on Evade innate IS / phagocytosis

Block degradation of IkBa

NFkB is not released and cannot induce pro-inflammatory cytokine signalling
- Salmonella

Altered MAMP/PAMP

Structure in/on bacterium that is hardly recognized by pathogen recognition receptor
- Flagellin not recognized by TLR5
- Campylobacter, Heliobacter

Antimicrobial peptide (AMP) - bind/degrading molecules - pathogen

Bind and degrade antimicrobial peptides to prevent damage to membrane
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Coagulase/fibronectin/hyaluronic acid

Clots fibrin/host extracellulair matrix factors on bacterial surface
- Bacterium recognized as host

Altered surface charge

Prevent action of cationic antimicrobial peptides

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